Long-form synthesis
Deep reports connect mechanisms, trials, outcomes, uncertainty, and the decisions the evidence can actually support.
54 open reports · claim-level qualified citations throughout · reviewed August 12, 2026
The State of Human Longevity Science in 2026
A field guide to what is established, what is promising, what has failed to clear the bar, and what evidence would change the picture.
Longevity Interventions: An Evidence-Tier Report
A claim-matched ranking of interventions—from proven disease and function outcomes to early human pharmacology and preclinical rejuvenation.
Biological Age Tests: A Technical and Consumer Interpretation Report
What clocks measure, why two tests disagree, which validation claims matter, and why a changed score is not yet a validated treatment outcome.
Cardiometabolic Medicines and Longevity Claims: A 2026 Evidence Map
A condition-first guide to GLP-1 drugs, SGLT2 inhibitors, statins, metformin, aspirin, and the difference between preventing events and treating aging.
Women's Midlife Health and Healthy Aging: A 2026 Evidence Report
An integrated guide to menopause symptoms, hormone therapy, cardiovascular and bone risk, muscle, sleep, cancer screening, and the evidence gaps women are too often asked to navigate alone.
Aging in the Real World: Environment, Senses, Medicines, and Equity
A deep report on the exposures and systems that shape function outside the laboratory: air, heat, hearing, vision, oral health, falls, medications, housing, access, and connection.
Brain Aging and Dementia in 2026: Prevention, Diagnosis, Treatment, and Care
A clinical evidence map from modifiable risk and acute confusion to blood biomarkers, anti-amyloid therapy, function, caregiving, and the limits of prevention claims.
Cardiovascular Aging Prevention in 2026: From Blood Pressure to Rhythm and Kidney Risk
A decision report on blood pressure, lipids, calcium scoring, atrial fibrillation, anticoagulation, kidney and diabetes risk, falls, and treatment burden in later life.
Preventive Screening in Older Adults: Benefit, Harm, and Time to Benefit
A framework for deciding when screening is likely to help, when added detection becomes a cascade, and how age, prior results, risk, function, and time horizon should change the conversation.
Cancer Prevention and Early Detection in 2026: What Improves Outcomes
A source-led report on tobacco, radon, activity, established screening programs, dense breasts, PSA, skin examination, overdiagnosis, and the difference between finding disease and improving life.
Sleep, Breathing, and Environmental Lung Health in 2026
A decision report on sleep apnea, COPD, smoking, radon, air pollution, vaccination, heat, lung screening, exercise, and the difference between population screening and symptom-led diagnosis.
Mental Health, Connection, Caregiving, and Serious-Illness Care in 2026
A practical evidence report connecting late-life depression, suicide prevention, loneliness, dementia caregiving, advance planning, palliative care, hospice, and hospital-at-home delivery.
Infectious Resilience in Later Life: Prevention, Recognition, Treatment, and Recovery
A 2026 evidence report connecting vaccination, COVID-19, Long COVID, sepsis, urine testing, antimicrobial resistance, C. difficile, delirium, environment, and recovery after severe infection.
Pain, Mobility, and Function in 2026: An Evidence-Based Care Architecture
A deep report on osteoarthritis, back pain, neuropathic pain, exercise, NSAIDs, opioids, falls, mood, sleep, frailty, and how to measure care by a life regained rather than a pain score alone.
Vision, Dizziness, Balance, and Independence in 2026
A practical report on cataract, macular degeneration, AREDS2, glaucoma, low-vision rehabilitation, dizziness, vestibular therapy, falls, medicines, sensory interaction, and accessible care.
Bone and Endocrine Aging in 2026: Fractures, Treatment Transitions, and Thyroid Restraint
A deep evidence report on osteoporosis screening, fracture prevention, vitamin D and calcium, exercise, bisphosphonate duration, denosumab rebound, secondary fracture systems, and subclinical hypothyroidism.
Oral Health, Chewing, Nutrition, and Systemic Claims in 2026
A deep evidence report on dry mouth, tooth decay, periodontal disease, dentures, chewing, nutrition, oral cancer, medicines, access, and the boundary between plausible systemic links and proven outcomes.
Urinary, Pelvic, Sexual, and Bowel Function in Later Life: A 2026 Evidence Architecture
A deep report connecting incontinence, pelvic floor training, genitourinary syndrome, recurrent UTI, BPH, erectile dysfunction, constipation, medicines, falls, cardiovascular risk, and person-centered function.
Hearing and Communication in Later Life: A 2026 Evidence and Access Report
A deep report on age-related hearing loss, hearing aids, cochlear implants, sudden loss, earwax, tinnitus, cognition, social function, falls, delirium, access, and communication-centered care.
Kidney and Liver Resilience in 2026: Detection, Medicines, Infection, and Fibrosis
A deep report connecting CKD detection, acute kidney injury, dehydration, medicine safety, SGLT2 therapy, MASLD fibrosis, resmetirom, hepatitis B and C, alcohol, supplements, and reliable transitions.
Digestive, Swallowing, Skin, and Wound Health in Later Life: A 2026 Evidence Report
A deep report on reflux and PPIs, H. pylori, diverticulitis, constipation, dysphagia, aspiration, oral care, sun protection, actinic keratosis, skin-cancer uncertainty, and pressure-injury prevention.
Neurologic Function in Later Life: Emergencies, Recovery, and Long-Term Support
A deep report on stroke and TIA, first seizure, Parkinson disease, peripheral neuropathy, giant cell arteritis, rehabilitation, medication safety, and the distinction between urgent rescue and longitudinal function.
Blood, Nutrients, and Inflammation in Later Life: A Diagnostic Evidence Report
A deep report on anemia, iron and B12 deficiency, blood loss, inflammatory disease, gout, rheumatoid arthritis, giant cell arteritis, medication effects, diagnostic reasoning, and monitored treatment response.
Rehabilitation as Longevity Care: A 2026 Systems Evidence Report
A deep report on cardiac, pulmonary, stroke, Parkinson, cancer, fracture, low-vision, vestibular, home-based, and multidisciplinary rehabilitation as a system for preserving activity and participation.
Cancer Survivorship and Healthspan: A 2026 Care Architecture
A deep report on treatment summaries, recurrence surveillance, second cancers, late effects, chronic disease, rehabilitation, mental and sexual health, supplements, care ownership, and the transition from oncology to lifelong healthspan care.
Late Effects of Cancer Treatment: A 2026 Exposure-to-Action Report
A deep report connecting systemic therapy, radiation, surgery, endocrine and immune therapy to cardiovascular, neurologic, cognitive, lymphatic, bone, endocrine, sexual, nutritional, and second-cancer consequences.
Supportive Cancer Care and Function: A 2026 Evidence Report
A deep report on fatigue, rehabilitation, exercise, neuropathy, lymphedema, cognition, nutrition, cachexia, sexual health, thrombosis, supplement safety, palliative care, caregiver load, and the systems that preserve life during and after cancer treatment.
Surgery and Recovery in Older Adults: A 2026 Decision-to-Home Report
A deep report on frailty, goals, prehabilitation, anesthesia and surgery pathways, delirium, pain, transfusion, mobility, nutrition, medication safety, discharge, rehabilitation, and measuring recovery that matters.
Hospital Hazards and Resilience: A 2026 Whole-System Report
A deep report on how illness, delirium, bed rest, sleep, medicines, nutrition, falls, pressure injury, sensory loss, devices, and fragmented transitions interact—and how an age-friendly system protects reserve.
After the ICU and Hospital: A 2026 Post-Acute Recovery Report
A deep report on post-intensive care syndrome, sepsis recovery, functional and cognitive assessment, medication and nutrition repair, post-acute setting choice, falls, caregiver capacity, follow-up, and days-at-home outcomes.
Safer Prescribing in Later Life: A 2026 Benefit-Burden Report
A deep report on appropriate polypharmacy, Beers and STOPP/START screening, indication and time to benefit, deprescribing evidence, prescribing cascades, kidney dosing, adherence, monitoring, transitions, and shared decisions.
Medicines, Brain, Falls, and Breathing: A 2026 Cumulative-Burden Report
A deep report on anticholinergic and sedative burden, benzodiazepines, opioids, gabapentinoids, sleep aids, orthostasis, hypoglycemia, delirium, falls, respiratory depression, tapering, and outcome monitoring.
The Reliable Medication System: A 2026 Home-to-Hospital Report
A deep report on authoritative medication lists, interactions, kidney dosing, administration, adherence, monitoring, prescribing and deprescribing, transitions, pharmacy coordination, accessibility, and correction loops.
Time-Sensitive Symptoms in Later Life: A 2026 Emergency Recognition Report
A deep report on recognizing and responding to acute coronary, pulmonary embolic, aortic, syncopal, heart-failure, gastrointestinal, abdominal, visual, allergic, metabolic, heat, and poisoning emergencies without attempting home diagnosis.
Emergency Readiness for Aging Well: A 2026 Information and Action Report
A deep report on the emergency information packet, medicines and devices, communication and decision support, transport, heat and outage planning, poison and overdose readiness, caregiver roles, transitions, and after-event learning.
Emergency Diagnostic Reasoning: A 2026 Probability, Testing, and Safety-Net Report
A deep report on pretest probability, rule-out thresholds, serial tests, false reassurance, incidental findings, treatment thresholds, shared uncertainty, discharge safety nets, and learning from diagnostic change.
Living Well With Dementia: A Care Architecture Report
A deep framework for diagnosis, supported autonomy, function, safety, medicines, daily life, behavioral change, care coordination, and review across a progressive and uncertain course.
Dementia Caregiver Health and Support: An In-Depth Evidence Report
A deep report on workload, health, skill, respite, service reliability, financial strain, crisis prevention, and what evidence can and cannot promise caregivers.
Home, Hospital, and Long-Term Care Decisions in Dementia
A setting-of-care report for comparing independence, safety, medical capability, caregiver capacity, cost, transitions, and the actual quality of daily life.
Chronic Wounds and Limb Preservation: A Cause-to-Healing Report
A deep report on wound diagnosis, perfusion, pressure, infection, edema, local care, nutrition, measurement, teams, and goal-concordant treatment.
Skin Cancer Prevention, Recognition, and Treatment: A 2026 Evidence Report
A deep evidence report on ultraviolet prevention, population screening uncertainty, lesion recognition, biopsy, melanoma and keratinocyte cancer risk, treatment, and survivorship.
Skin Integrity in Later Life: Barrier, Pressure, Tears, Edema, and Care Systems
A whole-system report on fragile skin, itch, tears, pressure, moisture, edema, infection, medicines, nutrition, caregiving, and escalation.
Autoimmune Rheumatic Disease and Healthspan: A 2026 Evidence Architecture
A deep report on diagnosis, disease targets, organ protection, function, cardiovascular and bone risk, infection, vaccination, monitoring, and the limits of immune-reset claims.
Safe Immunosuppression: A Medication-to-Life System Report
A deep operational report on indications, pretreatment screening, vaccination, laboratory monitoring, infection, cancer and reproductive risk, surgery, adherence, access, and stopping rules.
Organ Protection and Function in Systemic Autoimmune Disease
A deep report connecting kidney, lung, vessels, heart, bone, eye, mouth, muscle, brain, skin, nutrition, rehabilitation, and serious-illness decisions.
Reading Diagnostic and Screening Evidence: A 2026 Technical Guide
A deep guide to target conditions, reference standards, thresholds, accuracy, predictive value, calibration, verification, spectrum, screening outcomes, and diagnostic cascades.
Reading Clinical Trials for Longevity Decisions: A 2026 Deep Guide
A deep guide to questions, randomization, estimands, outcomes, clinical importance, composites, noninferiority, subgroups, missing data, harms, transport, and decision value.
Causal Inference Beyond Randomized Trials: A 2026 Evidence Map
A deep report on causal questions, target trials, confounding, immortal time, selection, measurement, missing data, negative controls, Mendelian randomization, triangulation, and responsible translation.
Auditing a Longevity Clinical Trial: A Design-to-Decision Report
A deep report on the causal question, allocation, blinding, outcomes, estimands, missing data, multiplicity, time-to-event analysis, harms, transportability, and decision-ready reporting.
Observational Longevity Evidence: A Bias-to-Triangulation Report
A deep report on target trials, time zero, confounding, healthy-user effects, indication, reverse causation, selection, measurement, missingness, sensitivity analysis, genetics, and independent triangulation.
From Systematic Review to Longevity Recommendation: A Certainty and Decision Report
A deep report on review questions, searching, duplicate study records, risk of bias, compatible synthesis, heterogeneity, missing evidence, certainty, absolute effects, and recommendation judgments.
Clinical Prediction and AI for Healthy Aging: A Validation-to-Governance Report
A deep report on prediction questions, data provenance, sample size, leakage, calibration, external validation, clinical utility, fairness, deployment, drift, updating, and retirement.
Innovative Trial Designs for Longevity Research: A 2026 Interpretation Guide
A deep report on pragmatic, cluster, crossover, factorial, adaptive, platform, pilot, and hybrid designs—what each gains, what each assumes, and how to read its claims.
A Reproducible Longevity Science System: From Question to Correction
A deep report on question discipline, prespecification, measurement, randomization, provenance, computational workflows, data and code sharing, replication, synthesis, living updates, governance, and correction.